PURPOSE: The refractive and visual outcomes of the presbyopic laser algorithm SUPRACOR with two different ablation profiles (strong and regular) using the TECHNOLAS TENEO 317 Model 2 Excimer Laser Platform were evaluated in this prospective, 12-month, randomized, single-surgeon study (NCT04617080).

METHODS: Sixty patients with presbyopia (36 myopic, 24 hyperopic) were treated bilaterally, with the dominant eye treated using the aspheric ablation profile PROSCAN, and the non-dominant eye randomized (1:1) to either SUPRACOR strong or SUPRACOR regular ablation profile with a refractive target of -0.50D. The primary outcome was binocular uncorrected (U) distance (D) visual acuity (VA) at 3 months. Secondary and other outcomes included manifest refraction spherical equivalent (MRSE), monocular and binocular VA at all distances (U, corrected [C], D, intermediate [I], and near [N]), defocus curve, contrast sensitivity, and patient-reported outcomes measures at 3 months and 12 months of follow up.

RESULTS: At 1-year post surgery, mean logMAR ± standard deviation (SD) binocular UDVA was -0.01±0.04 (regular) and 0.00±0.05 (strong); UIVA was 0.00±0.06 (regular) and 0.00±0.08 (strong); UNVA was 0.09±0.10 (regular) and 0.10±0.12 (strong); and CDVA was -0.01±0.03 (regular) and -0.01±0.04 (strong). Mean MRSE ± SD improved from -1.54±3.13D preoperatively to -0.57±0.47D post-operatively (regular), and from -2.84±2.81D to -0.71±0.56D (strong). No statistically significant differences were observed between groups. Binocular defocus curve reported useful VA (≥0.2 logMAR) up to -2.5D, and patient-reported questionnaires showed high spectacle independence for both groups.

CONCLUSION: Both SUPRACOR ablation profiles demonstrated restoration of VA at distance, intermediate and near distances, with the refractive target met. Patients treated with SUPRACOR regular or strong in the non-dominant eye and PROSCAN in the dominant eye achieved a high level of VA over the full range of distances.