This research evaluates the visual acuity outcomes and defocus curve following bilateral implantation of an enhanced monofocal IOL in cataract patients. The ambispective, single-arm study included 82 subjects who had undergone bilateral implantation of an enhanced monofocal IOL (enVista ASPIRE, Bausch and Lomb). Outcome measures assessed at least 2 months after IOL implantation in the second eye included monocular (first-implanted eye) and binocular visual acuities, as well as the binocular defocus curve. Postoperatively, mean monocular logMAR UDVA was 0.12±0.14 and CDVA was −0.01±0.09. Mean MRSE was −0.38±0.47 D. Mean monocular logMAR UIVA and UNVA were 0.2±0.15 and 0.42±0.17, with 58.5% and 34.1% of eyes achieving UIVA 20/32 or better, and UNVA 20/40 or better, postoperatively. Mean binocular logMAR DCIVA and DCNVA were 0.21±0.13 and 0.39±0.14, respectively, with 65.9% of patients achieving DCIVA 20/32 or better, and 35.4% achieving DCNVA 20/40 or better. Defocus curve showed 20/32 or better visual acuity for a defocus range of ~ +1.00 D to −1.25 D. In conclusion, implantation of an enhanced monofocal IOL increased the depth of focus, providing a mean uncorrected visual acuity of 20/26 at distance and 20/32 at intermediate.