PURPOSE: To compare the misalignment tolerance of Full Range of Vision (FRoV) intraocular lenses (IOLs).

METHODS: Optical bench testing evaluated the robustness to tilt and decentration of four FRoV IOLs: a new refractive Bausch & Lomb LuxLife and three diffractive (ALCON PanOptix, BVI FineVision, J&J Tecnis Synergy). The eye model used 550 nm light and a lens representative of a healthy cornea with 0.27 μm spherical aberration for 5.15 mm IOL pupil. Modulation Transfer Function (MTF) and area under the MTF from 0 to 50 cpmm (MTFa) were assessed for far vision with a 3.0 mm pupil in aligned, tilted (3°, 5°), and decentered (0.25, 0.50 mm) conditions.

RESULTS: LuxLife IOL exhibited superior MTF performance in aligned conditions and greater tolerance to decentration compared to other IOLs. LuxLife, PanOptix, and Synergy IOLs showed similar tolerance to tilt, outperforming FineVision.

CONCLUSIONS: LuxLife IOL demonstrated better robustness to misalignment, essential for real-world performance. While on-bench results indicate little impact on MTFa, further clinical studies are needed to correlate these findings with visual acuity and contrast sensitivity. Although study provides valuable insights, limitations include the use of monochromatic light, a single corneal aberration value, and a 3mm IOL pupil.