PURPOSE: Factors including age, refractive error, and luminance can affect pupil size and may influence the performance of multifocal contact lenses (MFCLs). This post-hoc analysis aimed to investigate correlations between pupil size and vision performance of a 3-Zone ProgressiveT design, daily disposable silicone hydrogel (kalifilcon A) MFCL.

METHODS: Habitual MFCL wearers aged =40 years were enrolled in a 3-week, single-arm, bilateral, open-label study to assess near, intermediate, and distant vision performance. Pupil sizes were recorded at dispensing, along with binocular high-contrast visual acuity (VA) by logMAR. VA was assessed at 1- and 3-weeks' follow-up for distance, intermediate, and near vision, and participants rated vision performance using a 0-100 scale (100=most favorable) at both these follow-ups. Responses with score =50 were considered favorable. Pearson correlation coefficient (r) was used to determine the correlation significance.

RESULTS: Pupil size ranged from 2.0 mm to 7.0 mm. Mean logMAR VA was -0.009, 0.046, and 0.114 (1 week), and -0.012, 0.046, and 0.115 (3 weeks) for distance, intermediate, and near vision, respectively. Statistical analysis of the VA distribution found no significant correlation between VA and pupil size after 1 week of MFCL wear for distance or near vision (r2=0.003 and 0.006, respectively; both p=0.05), and a weak but statistically significant correlation between intermediate VA and pupil size (r2=0.017; p<0.05). no correlations were observed after 3 weeks for any distance all p="0.05)." participants rated subjective vision highly 84.019.9 89.211.8 and 82.5 18.5 respectively at 1 week and 84.618.0 89.312.6 and 84.217.9 respectively at 3 weeks. responses were favorable at both visits p><0.05). correlations between vision rating and pupil size were not significant at either visit p="0.05).">

CONCLUSION: The kalifilcon A daily disposable silicone hydrogel MFCL delivers stable VA and significantly favorable (p<0.05) ratings at all distances for patients with a wide range of pupil sizes>