PURPOSE: To assess and compare pre-clinical glare phenomena, quantified by the straylight parameter, in the latest generation of presbyopia-correcting intraocular lenses (IOLs) from different manufacturers using a clinical straylight measurement system adapted for in vitro evaluation.

SETTING: David J. Apple Center for Vision Research, Department of Ophthalmology, University Eye Clinic Heidelberg, Heidelberg, Germany.

METHODS: A total of 18 IOLs were analyzed (6 groups, n = 3 per group), all with a nominal power of +20.0 D. Tested lenses included enVista Monofocal (Bausch + Lomb), enVista Envy (Bausch + Lomb), LuxLife (Bausch + Lomb), TECNIS Odyssey (Johnson & Johnson Vision), Clareon PanOptix Trifocal (Alcon), and FINEVISION HP (POD F GF) (BVI Medical). The potential of the IOLs to induce glare was quantified by means of forward light scattering using a C-Quant straylight meter (Oculus GmbH, Germany) adapted for in vitro assessment. Straylight was measured at visual angles of 2.5°, 3.5°, and 7°. The logarithm of the straylight parameter (logs) was used for analysis and reported in clinical log units; higher logs values are associated with increased perception of glare and larger halo size. Published straylight values of isolated crystalline lenses were used as physiological references.

RESULTS: At 7°, all IOLs demonstrated low straylight values (<0.3 logs), comparable to or below those of a young crystalline lens. At smaller visual angles (2.5° and 3.5°), angular dependency differed according to optical design. The monofocal enVista and the refractive trifocal IOL (LuxLife) showed consistently low straylight across all angles (≤0.3 logs). Among diffractive trifocal IOLs, enVista Envy and FINEVISION HP (POD F GF) maintained low and stable values. In contrast, TECNIS Odyssey exhibited elevated straylight at 2.5° and 3.5° (nearly 1.1 logs), approaching values reported for an aged crystalline lens, followed by a reduction at 7°. Clareon PanOptix demonstrated a moderate elevation at smaller angles.

CONCLUSIONS: Assessment at multiple visual angles reveals design-related differences in straylight, and thus glare perception, that are not detectable at 7° alone. Small-angle straylight differs among trifocal designs; the TECNIS Odyssey shows higher straylight at smaller angles, closer to a glaring source. By contrast, enVista Envy and FINEVISION maintained low straylight levels, close to those of the refractive IOLs.